Big Fat Reference Guide

Welcome to the Big Fat Reference Guide!

The Big Fat Reference Guide for Alpha-1 (BFRG) is the most comprehensive guide to living with Alpha1-Antitrypsin Deficiency available anywhere.


The BFRG provides detailed information specific to Alpha-1 and includes information about testing and treatment, diet and nutrition, activity and fitness, the management of environmental risk factors, coping with Alpha-1, insurance and disability and much more.


For Healthcare Providers, the BFRG helps in the evaluation, diagnosis, and management of patients with Alpha-1.

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